Let’s look at a few times the Lord spoke directly to someone in the Bible.

ADAM – Genesis 2:16-17, “And the LORD God commanded the man, saying, Of every tree of the garden thou mayest freely eat: But of the tree of the knowledge of good and evil, thou shalt not eat of it: for in the day that thou eatest thereof thou shalt surely die.” For a time, the Lord walked and spoke with Adam frequently, but these are the first words we have that tell what the Lord said to Adam.

CAIN – Genesis 4:6, “And the LORD said unto Cain, Why art thou wroth? and why is thy countenance fallen?” When Abel’s offering to the Lord was accepted, Cain became very angry that his offering was not accepted. In great love, the Lord came to Cain and tried to get him to see that he could be accepted with the proper sacrifice.

NOAH – Genesis 6:12-13, “And God looked upon the earth, and, behold, it was corrupt; for all flesh had corrupted his way upon the earth. And God said unto Noah, The end of all flesh is come before me; for the earth is filled with violence through them; and, behold, I will destroy them with the earth.” The Lord begins to show Noah His plans to flood the earth because of the great sins of man.

MOSES – Exodus 3:4-5, “And when the LORD saw that he turned aside to see, God called unto him out of the midst of the bush, and said, Moses, Moses. And he said, Here am I. And he said, Draw not nigh hither: put off thy shoes from off thy feet, for the place whereon thou standest is holy ground.” In his lifetime, the Lord spoke many times to Moses. This is the first time He spoke to Moses.

SAMUEL – 1 Samuel 3:10, “And the LORD came, and stood, and called as at other times, Samuel, Samuel. Then Samuel answered, Speak; for thy servant heareth.”

DAVID – 1 Samuel 23:2, “Therefore David inquired of the LORD, saying, Shall I go and smite these Philistines? And the LORD said unto David, Go, and smite the Philistines, and save Keilah.”

SAUL (The Apostle Paul) – Acts 9:3-4, “And as he journeyed, he came near Damascus: and suddenly there shined round about him a light from heaven: And he fell to the earth, and heard a voice saying unto him, Saul, Saul, why persecutest thou me?”

I can’t say for sure how many people the Lord spoke to directly. Searching the Word in order to answer your good question, I found about 25 different people to whom the Lord spoke directly. Let’s look at Hebrews 1:1-2, “God, who at sundry times and in divers manners spake in time past unto the fathers by the prophets, Hath in these last days spoken unto us by his Son, whom he hath appointed heir of all things, by whom also he made the worlds.”

We are told that the Lord spoke to the Jewish fathers through the prophets. Rather than speak to all people individually, the Lord spoke directly to the prophets so that they might write what the Lord instructed them to write. “In these last days” the Lord speaks to us in the person of His Son. How does He do that? The Lord speaks to us through His Word. Christ IS the Word, as we read in John 1:1, “In the beginning was the Word, and the Word was with God, and the Word was God.”

Do you long to hear the voice of God? Do you want to hear from the Lord so that He might direct you in your life? Do you want to hear His tender words of comfort when you are suffering or grieving? Read God’s Word! He will speak to you through His Word loud and clear when you read His Word with a willing heart to obey what He says to you. (338.6)